celtic knot

Combinatorial Chemistry:
A Business Overview
Table of Contents

Executive Summary
I. Introduction
A. What is Combinatorial Chemistry?
B. How does Combinatorial Chemistry work?
C. History of Combinatorial Chemistry
D. Drawbacks and limitations to Combinatorial Chemistry
E. Combinatorial Biology
II. General Trends in Research and Development
A. Developments in the industry
  1. Downsizing
  2. Outsourcing
  3. Decreasing time to market
B. Corporate Strategies in R&D
  1. Joint Ventures/Alliances
  2. Mergers/Acquisitions
  3. Collaborative Research/Consortiums
  4. Contract research organization
III. The Many Approaches to Combinatorial Chemistry
A. Theory of Combinatorial Chemistry
B. Design of Combinatorial Libraries
C. Methods Used to Make Combinatorial Libraries
D. Screening Combinatorial Libraries
E. Analysis of Combinatorial Libraries
IV. Information Management and Instrumentation in Combinatorial Chemistry
V. Markets for Combinatorial Chemistry
A. Pharmaceuticals
B. Biotechnology
C. Agrochem
D. Enzymes/Catalysis
E. Chiral chemicals
F. Semiconductor Industry
F. Cosmetics
G. Diagnostic Imaging
H. Advanced Separations
I. Biosensors, Bioelectronics, Nanotechnology
VI. Combinatorial Chemistry Companies
A. The early acquired companies
Genesis Pharmaceuticals
Selectide Corp.
Sphinx Pharmaceuticals
Affymax
B. Major Players in Combinatorial Chemistry
3-Dimensional Pharmaceuticals
Agouron Pharmaceuticals
Alanex Corp./Agouron
Ariad Pharmaceuticals
Arris Pharmaceuticals
ArQule, Inc.
Aurora Biosciences
Cadus Pharmaceuticals
Chemgenics Pharmaceuticals/Millenium
Chiron Technologies
Corvas International
CombiChem, Inc.
Cubist Pharmaceuticals
Darwin Molecular/ Chiroscience Group
Dyax Corp.
Gilead Sciences
Houghten Pharmaceuticals/Trega Biosciences
Irori Quantum Microchemistry

ISIS Pharmaceuticals
Ixsys, Inc.
La Jolla Pharmaceuticals
Ligand Pharmaceuticals
Molecumetics, Ltd.
Neurogen Corp.
NeXstar Pharmaceuticals
Oncogene Science, Inc.
Ontogen Corp.
Peptide Therapeutics
Pharmacopeia
Pharmagenics, Inc.
Repligen
Signal Pharmaceuticals
Symyx Technologies
Terrapin Technologies
Vertex Pharmaceuticals
Xenova Group
C. Additional Combinatorial Chemistry Companies
Acacia Biosciences, Aptein, Auda Pharmaceuticals, Cambridge Combinatorial, Cerep, ComGenex, Diversomer Technologies, ICAgen, Pharm-Eco, Pharmaceutical Peptides/Praecis Pharmaceuticals, Oxford Asymmetic, Recombinant Biocatalysis, Sphere Biosystems, ThermoGen, Tripos/Panlabs, Versicor
D. Combinatorial Biology Companies
ChromaXome/Trega Biosciences
Kosan Biosciences
MorphoSys
Oceanix Biosciences
E. Cheminformatic Companies
Chemical Design
Daylight Chemical
MDL Information Systems
Molecular Simulations
Tripos
Others: Bionumerik, CyberChemics, InfoChem, Pangea, Structural Bioinformatics
F. Instrumentation Companies
Advanced ChemTech
Argonaut Technologies
Gilson
Perkin-Elmer/SCIEX
Packard Instruments
Others: Affinity Biosensors, Evotec Biosystems, Orchid Biocomputer, Pharmacia Biosensors
VII. Universities and Non-Profit Organizations
VIII. Combinatorial Chemistry company collaborative research agreements
A. Collaborations outside biotechnology
B. Intra-biotech collaborations
C. Collaborations and licensing with universities and non-profit organizations
IX. What is Combinatorial Chemistry worth?
A. Value based on collaborations
B. Theoretical value based on potential products in various industries
X. The future of Combinatorial Chemistry
Appendix
A. Key Patents in Combinatorial Chemistry
B. Glossary
C. Information Sources
D. Bibliographies


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